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Osamu Miyashita

Date of Birth: January 7, 1974

University of California at San Diego,
Department of Physics,
9500 Gilman Drive,
La Jolla, CA 92093, USA
+1-858-534-7337
omiyashita at ucsd dot edu



RESEARCH INTERESTS

EDUCATIONS

November 2000

Kyoto University Graduate School of Science, Kyoto, Japan
Ph.D. on Science, Role of Conformational Dynamics on Electron and Energy Transfer in a Protein Molecule
Supervisor: Prof. Nobuhiro Go
Collaborator: Prof. Akinori Kidera

March 1998

Kyoto University Graduate School of Science, Kyoto, Japan
Master Degree on Science

March 1996

Kyoto University Graduate School of Science, Kyoto, Japan
Bachelor Degree on Science

POSTDOCTORAL TRAINING

November 2000 - present

Postdoctoral Fellow at University of California, San Diego, Department of Physics
Mentor: Prof. José N. Onuchic
Co-Mentor: Prof. Melvin Y. Okamura
Collaborator: Prof. Peter G. Wolynes


PROFESSIONAL EXPERIENCES

November 1999 - October 2000 President of the Society of Young Biophysical Researchers of Japan
April 1999 - December 1999 Computer System Administrator, Kyoto University Graduate School of Science, Department of Chemistry
September 1998 - March 1999 Teaching Assistant, Kyoto University Graduate School of Science, Department of Chemistry

HONOR, AWARDS

November 2001 - present Postdoctoral Fellowship of La Jolla Interfaces in Science from Burroughs Wellcome Fund
January 2000 - October 2001 Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
July 2001 Travel Fellow Grant of the 4th International Conference on Biological Physics, ICBP2001, Kyoto, Japan
September 1999 Travel Fellow Grant of XIII International Biophysics Congress, New Delhi, India

PUBLICATIONS

Doctoral Thesis

Osamu Miyashita (2000). Role Of Conformational Dynamics On Electron And Energy Transfer In A Protein Molecule. PhD thesis, Kyoto University, Kyoto, Japan


Research Papers

  1. Miyashita, O; Okamura, MY; Onuchic, JN. 2005. Interprotein electron transfer from cytochrome c(2) to photosynthetic reaction center: Tunneling across an aqueous interface. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (10): 3558-3563.
  2. Wong, L; Lieser, SA; Miyashita, O; Miller, M; Tasken, K; Onuchic, JN; Adams, JA; Woods, VL; Jennings, PA. 2005. Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. JOURNAL OF MOLECULAR BIOLOGY 351 (1): 131-143.
  3. Miyashita, O; Wolynes, PG; Onuchic, JN. 2005. Simple energy landscape model for the kinetics of functional transitions in proteins. JOURNAL OF PHYSICAL CHEMISTRY B 109 (5): 1959-1969.
  4. Miyashita, O; Onuchic, JN; Okamura, MY. 2004. Transition state and encounter complex for fast association of cytochrome c(2) with bacterial reaction center. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (46): 16174-16179.
  5. Tama, F; Miyashita, O; Brooks, CL. 2004. Normal mode based flexible fitting of high-resolution structure into low-resolution experimental data from cryo-EM. JOURNAL OF STRUCTURAL BIOLOGY 147 (3): 315-326.
  6. Wong, L; Lieser, S; Chie-Leon, B; Miyashita, O; Aubol, B; Shaffer, J; Onuchic, JN; Jennings, PA; Woods, VL; Adams, JA. 2004. Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. JOURNAL OF MOLECULAR BIOLOGY 341 (1): 93-106.
  7. Tama, F; Miyashita, O; Brooks, CL. 2004. Flexible multi-scale fitting of atomic structures into low-resolution electron density maps with elastic network normal mode analysis. JOURNAL OF MOLECULAR BIOLOGY 337 (4): 985-999.
  8. Miyashita, O; Onuchic, JN; Wolynes, PG. 2003. Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 12570-12575.
  9. Miyashita, O; Onuchic, JN; Okamura, MY. 2003. Continuum electrostatic model for the binding of cytochrome c(2) to the photosynthetic reaction center from Rhodobacter sphaeroides. BIOCHEMISTRY 42 (40): 11651-11660.
  10. Moritsugu, K; Miyashita, O; Kidera, A. 2003. Temperature dependence of vibrational energy transfer in a protein molecule. JOURNAL OF PHYSICAL CHEMISTRY B 107 (14): 3309-3317.
  11. Miyashita, O; Okamura, MY; Onuchic, JN. 2003. Theoretical understanding of the interprotein electron transfer between cytochrome c(2) and the photosynthetic reaction center. JOURNAL OF PHYSICAL CHEMISTRY B 107 (5): 1230-1241.
  12. Miyashita, O; Axelrod, HL; Onuchic, JN. 2002. Different scenarios for inter-protein electron tunneling: The effect of water-mediated pathways. JOURNAL OF BIOLOGICAL PHYSICS 28 (3): 383-394.
  13. Tama, F; Miyashita, O; Kitao, A; Go, N. 2000. Molecular dynamics simulation shows large volume fluctuations of proteins. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 29 (7): 472-480.
  14. Moritsugu, K; Miyashita, O; Kidera, A. 2000. Vibrational energy transfer in a protein molecule. PHYSICAL REVIEW LETTERS 85 (18): 3970-3973.
  15. Miyashita, O; Go, N. 2000. Reorganization energy of protein electron transfer reaction: Study with structural and frequency signature. JOURNAL OF PHYSICAL CHEMISTRY B 104 (31): 7516-7521.
  16. Miyashita, O; Go, N. 1999. Pressure dependence of protein electron transfer reactions: Theory and simulation. JOURNAL OF PHYSICAL CHEMISTRY B 103 (3): 562-571.